Southeast Missouri Vacations

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Find the Best Southeast Missouri Vacation Packages

Southeast Missouri Hotel Deals

Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is NT$2,061 per night from Jan 27 to Jan 28
NT$2,061
NT$2,350 total
includes taxes & fees
Jan 27 - Jan 28
7.2/10 Good! (1,001 reviews)
"Quick trip. Just needed a stopover. Comfy beds clean room"

Reviewed on 2025/1/13

Days Inn and Suites by Wyndham Sikeston
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is NT$1,704 per night from Feb 23 to Feb 24
NT$1,704
NT$1,940 total
includes taxes & fees
Feb 23 - Feb 24
8/10 Very Good! (842 reviews)
"Can be noisy at times"

Reviewed on 2025/1/20

Baymont Inn and Suites by Wyndham Farmington, MO
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
The price is NT$2,360 per night from Feb 3 to Feb 4
NT$2,360
NT$2,489 total
includes taxes & fees
Feb 3 - Feb 4
7.8/10 Good! (1,000 reviews)
"Clean room"

Reviewed on 2025/1/8

Motel 6 Poplar Bluff, MO
See all 538 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You’ll find deals on flights, hotels, tours and more that’ll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you’ll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you’re considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It’s tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can’t book ahead, don’t worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you’re taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you’ve made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you’ll pick up terrific discounts. Whether you’re planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you’re spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you’ve booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.

Discover the most popular places to visit in Southeast Missouri

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

4.5/5(8 reviews)

Explore the great outdoors at Echo Bluff State Park, a lovely green space in Salem. While you're in the area, stroll along the riverfront.

Echo Bluff State Park

Isle Casino Cape Girardeau

4.5/5(48 reviews)

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

Isle Casino Cape Girardeau

Sainte Genevieve Winery

4/5(8 reviews)

You can enjoy a tasting or tour at Sainte Genevieve Winery during your travels to Ste Genevieve. Take in the entertainment venues while you're in the area.

Sainte Genevieve Winery
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.