South San Diego Vacations

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Where to stay in South San Diego

Find the best South San Diego areas and neighborhoods for the activities you enjoy most. Learn more about South San Diego
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Otay Mesa West

Even though there aren't top sights in Otay Mesa West, you can explore the larger area and take in top sights like San Ysidro Border Crossing. Jump on the metro at Iris Avenue Trolley Station to see more of the city.

Find hotels in Otay Mesa West

Find the Best South San Diego Vacation Packages

South San Diego Hotel Deals

San Diego Marriott La Jolla
San Diego Marriott La Jolla
4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
Fully refundableReserve now, pay when you stay
The price is NT$5,975 per night from May 9 to May 10
NT$5,975
NT$6,739 total
includes taxes & fees
May 9 - May 10
8.4/10 Very Good! (1,722 reviews)
"Staff was prompt and friendly checking me in. Even the lady at the Starbucks the next morning was so sweet. My room, bedding, and towels were all clean. I slept well."

Reviewed on 2025/4/20

San Diego Marriott La Jolla
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NT$5,150 per night from Apr 28 to Apr 29
NT$5,150
NT$5,803 total
includes taxes & fees
Apr 28 - Apr 29
8.8/10 Excellent! (3,334 reviews)
"Great!"

Reviewed on 2025/4/20

The Dana on Mission Bay
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NT$6,121 per night from May 4 to May 5
NT$6,121
NT$8,496 total
includes taxes & fees
May 4 - May 5
8.2/10 Very Good! (1,181 reviews)
"The property, amenities, and convenience of this resort were outstanding! However, we definitely wish that our room (Traditional King Room) had more lighting; our room only had two bedside lamps. Nevertheless, our stay at the resort was fantastic and the ease-of-access to the bay to walk, dine, and ..."

Reviewed on 2025/4/21

San Diego Mission Bay Resort
See all 7,520 properties in South San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a South San Diego vacation package cost?
Chart your own course with our South San Diego vacation packages, which start from only . Select the flights and hotels that suit your travel style. Then, add on a few sightseeing activities for an unforgettable escape.
How do I get a cheap travel package to South San Diego?
Browse and book everything all in one place with our South San Diego vacation packages. You’ll find deals on hotels, flights, tours and more that’ll keep your pocketbook happy and your spirit of adventure alive. And, with more than 550 partner airlines and 1,000,000 hotel options around the world to choose from, there are endless opportunities to mix and match as you like.
What are the top hotels in South San Diego?
Have a look at Wyndham San Diego Bayside and Manchester Grand Hyatt San Diego. They’re top picks for lots of travelers to Chula Vista. If Imperial Beach features on your itinerary, Hard Rock Hotel San Diego and Best Western Plus Marina Gateway Hotel are two top-notch options.
How far in advance should I book my South San Diego vacation?
Travelers can normally compare international fares on Expedia up to a year in advance of departure. Booking late? With a little bit of luck, it’s still possible to score a cheaper ticket just weeks before your journey.
What does an Expedia South San Diego travel package include?
Flights, hotels and a shiny set of wheels for all your road trip adventures. Simply select your preferred bundle and get access to incredible deals. Once you’ve made your booking, add on a couple of tours and activities and watch your savings pile up. When it comes to crafting your South San Diego escape, you’re the boss!
What should I know before booking a South San Diego travel package?
A package can be easier on the wallet than separately booking everything you need for your escape. For example, bundle your flights, hotels and rental cars and save a packet. Whatever sort of vacation you’re planning, you’re sure to find a package within your budget.
Can I choose my airline with a South San Diego Expedia vacation package?
With a vacation package, you’re in charge. Whether you’re eager to fly to South San Diego in economy or business class, simply select from the available airline options. Expedia has access to over 550 airline partners around the world.
If I'm not able to travel, can I cancel my South San Diego vacation package?
You can. We realize things don’t always go to plan, so we’re here to help if you need to make changes to your South San Diego vacation package. It may be possible to cancel or amend your itinerary at no cost if you’ve booked in the last 24 hours. Your airline, hotel or car rental company may charge you a fee if you booked more than 24 hours ago. Visit our Customer Service Portal for further information. Also, be sure to check your itinerary for the finer details on change fees.

Discover the most popular places to visit in South San Diego

Chula Vista Center

3.5/5(3 reviews)

During your visit to Chula Vista, you can do some window-shopping at Chula Vista Center. Wander the beautiful beaches and waterfront in this family-friendly area.

Chula Vista Center

Eastlake Country Club

5/5(1 review)

Enjoy a round of golf in Chula Vista at Eastlake Country Club. Stroll along the beautiful beaches in this family-friendly area, or check out its top-notch restaurants.

Eastlake Country Club

Kaiser Permanente Otay Mesa Medical Offices

4.5/5(3 reviews)

Though Kaiser Permanente Otay Mesa Medical Offices might be what brings you to town, perhaps you'll have a chance to explore more of San Diego while you are here.

Kaiser Permanente Otay Mesa Medical Offices
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.