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Find hotels in South Main, Houston from NT$1,541

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Apr 5 - Apr 6
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Apr 6 - Apr 7
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Apr 11 - Apr 13
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Apr 18 - Apr 20

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Discover 6,204 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Comfort Suites near Texas Medical Center - NRG Stadium
Lobby

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (821)
"Extremely good value for money"
The price is NT$3,163
NT$3,701 total
includes taxes & fees
Apr 29 - Apr 30
Comfort Suites near Texas Medical Center - NRG Stadium
Wyndham Houston near NRG Park/Medical Center
View from property

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1016)
"Love the room! Was very clean, and amazing "
The price is NT$5,904
NT$6,908 total
includes taxes & fees
Apr 7 - Apr 8
Wyndham Houston near NRG Park/Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.6 out of 10, Good, (749)
"Good overall, there was no tv remote, no trash can in kitchen and chair was not clean. Some red water came out from bathtub faucet when opened first time. Overall good. "
The price is NT$2,637
NT$3,086 total
includes taxes & fees
Apr 27 - Apr 28
Candlewood Suites Houston Medical Center by IHG
Quality Inn & Suites NRG Park - Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1000)
"Area was super close to MD Anderson, which was awesome for me as we were visiting some family that we have there worked as a great place to escape when we needed a moment or didn’t want to buy a breakfast. They also had breakfast there overall great experience if you’re looking for a cheap hotel that isn’t gonna cost you $600 for the week this would be a great place to go!"
The price is NT$2,047
NT$2,395 total
includes taxes & fees
Apr 28 - Apr 29
Quality Inn & Suites NRG Park - Medical Center
OYO Hotel Houston Tx Medical Center Nrg Stadium
Lobby

OYO Hotel Houston Tx Medical Center Nrg Stadium

2.5 star property
3.8 out of 10, (425)
"Closed down "
OYO Hotel Houston Tx Medical Center Nrg Stadium
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Pillowtop beds, desk, iron/ironing board, free WiFi

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

3.5 star property
9.2 out of 10, Wonderful, (926)
"Everything was amazing "
The price is NT$2,525
NT$2,903 total
includes taxes & fees
Apr 27 - Apr 28
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Sonesta Simply Suites Houston – NASA Clear Lake
Fridge, microwave, stovetop, dishwasher

Sonesta Simply Suites Houston – NASA Clear Lake

2.5 star property
8.2 out of 10, Very Good, (886)
"Staff was great!!!!"
The price is NT$2,077
NT$2,430 total
includes taxes & fees
Apr 28 - Apr 29
Sonesta Simply Suites Houston – NASA Clear Lake
SureStay Hotel by Best Western Deer Park
In-room safe, individually furnished, desk, laptop workspace

SureStay Hotel by Best Western Deer Park

2.5 star property
8.6 out of 10, Excellent, (218)
"Last minute booking and was perfect. "
The price is NT$2,374
NT$2,777 total
includes taxes & fees
Apr 15 - Apr 16
SureStay Hotel by Best Western Deer Park
La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA
Suite, 2 Queen Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free cribs/infant beds

La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA

3.0 star property
7.8 out of 10, Good, (1001)
"We enjoyed our stay. Comfortable beds. Very clean. Friendly and caring staff and great customer service. Good breakfast. "
The price is NT$2,270
NT$2,656 total
includes taxes & fees
Apr 13 - Apr 14
La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA
Best Western Webster Hotel, Nasa
Seasonal outdoor pool, pool umbrellas, sun loungers

Best Western Webster Hotel, Nasa

2.5 star property
7.6 out of 10, Good, (1001)
"There was a variety of activities to do around the immediate vicinity of the hotel. The breakfast options were limited and not very appetizing, but the room itself was clean and comfortable to spend the day in."
The price is NT$2,083
NT$2,437 total
includes taxes & fees
Apr 21 - Apr 22
Best Western Webster Hotel, Nasa
La Quinta Inn & Suites by Wyndham Houston Channelview
Exterior

La Quinta Inn & Suites by Wyndham Houston Channelview

3.5 star property
8.6 out of 10, Excellent, (710)
"The staff was so friendly and the hotel is just like the pictures! Nice and clean!"
The price is NT$2,643
NT$3,092 total
includes taxes & fees
Apr 27 - Apr 28
La Quinta Inn & Suites by Wyndham Houston Channelview
Holiday Inn Express & Suites Houston East - Beltway 8 by IHG
Exterior

Holiday Inn Express & Suites Houston East - Beltway 8 by IHG

2.5 star property
8.4 out of 10, Very Good, (378)
"amazing stay no complaints "
The price is NT$2,967
NT$3,471 total
includes taxes & fees
Apr 27 - Apr 28
Holiday Inn Express & Suites Houston East - Beltway 8 by IHG
Palace Inn Blue Houston East Beltway 8
Reception

Palace Inn Blue Houston East Beltway 8

2.5 star property
9.0 out of 10, Wonderful, (257)
"It was overall a decent place to stay. The room was still a little dirty when we entered the bathroom room. Don’t expect eggs or any warm food for breakfast. All they had was cereal,muffins,honey buns and some fruit. The rest of the room was really comfortable and put together if you’re just looking for a place to stay then I recommend."
The price is NT$2,522
NT$2,900 total
includes taxes & fees
Apr 20 - Apr 21
Palace Inn Blue Houston East Beltway 8
La Quinta Inn & Suites by Wyndham Pasadena North
Lobby

La Quinta Inn & Suites by Wyndham Pasadena North

3.0 star property
7.8 out of 10, Good, (548)
"Buena opción para descansar"
The price is NT$2,716
NT$3,178 total
includes taxes & fees
May 5 - May 6
La Quinta Inn & Suites by Wyndham Pasadena North
Bluestar Inn
Individually furnished, desk, iron/ironing board, free WiFi

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (210)
"Great place to stay for the money. New build and amazing showers"
The price is NT$2,407
NT$2,816 total
includes taxes & fees
Apr 6 - Apr 7
Bluestar Inn
Best Western Plus Pasadena Inn and Suites
Lobby

Best Western Plus Pasadena Inn and Suites

2.5 star property
8.6 out of 10, Excellent, (380)
"Good service "
The price is NT$2,914
NT$3,410 total
includes taxes & fees
Apr 12 - Apr 13
Best Western Plus Pasadena Inn and Suites
Best Western Plus Heritage Inn
Reception

Best Western Plus Heritage Inn

3.0 star property
8.0 out of 10, Very Good, (614)
"Hotel and staff are great room was clean."
The price is NT$2,581
NT$3,020 total
includes taxes & fees
Apr 6 - Apr 7
Best Western Plus Heritage Inn
Woodspring Suites South Houston Hobby
Suite, 1 King Bed, Non Smoking | Individually furnished, desk, laptop workspace, bed sheets

Woodspring Suites South Houston Hobby

2.5 star property
7.8 out of 10, Good, (177)
"I liked everything about it I wasn't ready to leave & will be staying there again soon"
The price is NT$2,110
NT$2,469 total
includes taxes & fees
Apr 7 - Apr 8
Woodspring Suites South Houston Hobby
Palace Inn Blue Edgebrook
Free daily on-the-go breakfast

Palace Inn Blue Edgebrook

2.5 star property
9.2 out of 10, Wonderful, (94)
"Very clean with nice rooms."
The price is NT$2,917
NT$3,515 total
includes taxes & fees
Apr 20 - Apr 21
Palace Inn Blue Edgebrook
Sonesta Essential Houston Hobby Airport
Lobby

Sonesta Essential Houston Hobby Airport

2.5 star property
6.6 out of 10, (1005)
"Nice although alot if strict rules, they do not allow pets as stated on Expedia, staff has strict rules to extend or rebook before 11 am or else you wait downstairs to check in again til 3 pm. Nice hot breakfast."
The price is NT$1,541
NT$1,996 total
includes taxes & fees
May 6 - May 7
Sonesta Essential Houston Hobby Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Wyndham Houston near NRG Park/Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 67 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.