Photo by Hazem Abdul

Find hotels in South Main, Houston from NT$1,315

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Tonight
Feb 1 - Feb 2
Tomorrow
Feb 2 - Feb 3
Next weekend
Feb 7 - Feb 9
In two weeks
Feb 14 - Feb 16

Filter by

Guest rating
Guest rating
Star rating

Discover 6,380 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Comfort Suites near Texas Medical Center - NRG Stadium
Lobby

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (756)
"Okay"
The price is NT$2,908
NT$3,402 total
includes taxes & fees
Feb 17 - Feb 18
Comfort Suites near Texas Medical Center - NRG Stadium
Wyndham Houston near NRG Park/Medical Center
View from property

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.4 out of 10, Good, (1015)
"Ms. Angela at the front desk, is a special kind of person!! She is the sweetest person and she knows how to handle guests with so much kindness it’s heartwarming!!"
The price is NT$3,399
NT$3,977 total
includes taxes & fees
Feb 2 - Feb 3
Wyndham Houston near NRG Park/Medical Center
Candlewood Suites Houston Medical Center, an IHG Hotel
Exterior

Candlewood Suites Houston Medical Center, an IHG Hotel

2.5 star property
7.6 out of 10, Good, (728)
"Probably will not stay there again. Other properties in the area are much better. Homeless camped out right in front of the building. "
The price is NT$2,059
NT$2,409 total
includes taxes & fees
Feb 8 - Feb 9
Candlewood Suites Houston Medical Center, an IHG Hotel
Wingate Houston near NRG Park/Medical Center
Room, 2 Double Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.8 out of 10, (809)
"Very helpful. Clean . Staff was so polite. Enjoyed the breakfast. "
The price is NT$2,909
NT$3,403 total
includes taxes & fees
Feb 2 - Feb 3
Wingate Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1002)
"Hallway carpet needs cleaning and heaters need to be operational "
The price is NT$2,255
NT$2,638 total
includes taxes & fees
Feb 2 - Feb 3
Quality Inn & Suites NRG Park - Medical Center
OYO Hotel Houston Tx Medical Center Nrg Stadium
Lobby

OYO Hotel Houston Tx Medical Center Nrg Stadium

2.5 star property
3.8 out of 10, (412)
"I did not get to stay. I booked threw expedia. Arrived to be sentvaway because the motel was already at full capacity"
The price is NT$1,315
NT$1,735 total
includes taxes & fees
Feb 16 - Feb 17
OYO Hotel Houston Tx Medical Center Nrg Stadium
La Quinta Inn & Suites by Wyndham Deer Park
Exterior

La Quinta Inn & Suites by Wyndham Deer Park

2.5 star property
8.4 out of 10, Very Good, (366)
"Only thing that could use some improvement is the breakfast food options. "
The price is NT$2,745
NT$3,212 total
includes taxes & fees
Mar 2 - Mar 3
La Quinta Inn & Suites by Wyndham Deer Park
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Pillowtop beds, desk, iron/ironing board, free WiFi

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

3.5 star property
9.2 out of 10, Wonderful, (882)
"Had a easy checkin and check out. Super quiet and clean. "
The price is NT$2,171
NT$2,496 total
includes taxes & fees
Feb 23 - Feb 24
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Sonesta Simply Suites Houston – NASA Clear Lake
Fridge, microwave, stovetop, dishwasher

Sonesta Simply Suites Houston – NASA Clear Lake

2.5 star property
8.2 out of 10, Very Good, (823)
"Everything about this property is very much Excellent very clean very safe very family oriented. The staff are amazing. I love it here.LOVE "
The price is NT$2,059
NT$2,409 total
includes taxes & fees
Feb 12 - Feb 13
Sonesta Simply Suites Houston – NASA Clear Lake
SureStay Hotel by Best Western Deer Park
In-room safe, individually furnished, desk, laptop workspace

SureStay Hotel by Best Western Deer Park

2.5 star property
8.4 out of 10, Very Good, (199)
"Huge room, nice staff "
The price is NT$2,265
NT$2,650 total
includes taxes & fees
Feb 14 - Feb 15
SureStay Hotel by Best Western Deer Park
stayAPT Suites Houston NASA Clear Lake
Exterior

stayAPT Suites Houston NASA Clear Lake

2.5 star property
9.4 out of 10, Exceptional, (260)
"Clean, tidy and new apartments with plenty of space and good facilities. Driveway signage needs lighting as it is a little dark and hard to see."
The price is NT$3,431
NT$4,014 total
includes taxes & fees
Feb 3 - Feb 4
stayAPT Suites Houston NASA Clear Lake
La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA
Suite, 2 Queen Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free cribs/infant beds

La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA

2.5 star property
7.8 out of 10, Good, (1008)
"Very clean and excellent room"
The price is NT$2,306
NT$2,698 total
includes taxes & fees
Feb 23 - Feb 24
La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA
Best Western Webster Hotel, Nasa
Seasonal outdoor pool, pool umbrellas, sun loungers

Best Western Webster Hotel, Nasa

2.5 star property
7.6 out of 10, Good, (1002)
"The Staff was so very helpful, Cordial, Professional. Really, Great Staff. I thought I was dealing with 5 Star Hotel. Kudos,!"
The price is NT$2,173
NT$2,542 total
includes taxes & fees
Feb 23 - Feb 24
Best Western Webster Hotel, Nasa
La Quinta Inn & Suites by Wyndham Houston Channelview
Exterior

La Quinta Inn & Suites by Wyndham Houston Channelview

3.5 star property
8.6 out of 10, Excellent, (680)
"Great last minute decision "
The price is NT$2,546
NT$2,979 total
includes taxes & fees
Feb 16 - Feb 17
La Quinta Inn & Suites by Wyndham Houston Channelview
Palace Inn Blue Houston East Beltway 8
Reception

Palace Inn Blue Houston East Beltway 8

2.5 star property
9.0 out of 10, Wonderful, (242)
"N/_"
The price is NT$2,500
NT$2,875 total
includes taxes & fees
Feb 17 - Feb 18
Palace Inn Blue Houston East Beltway 8
La Quinta Inn & Suites by Wyndham Pasadena North
Lobby

La Quinta Inn & Suites by Wyndham Pasadena North

2.5 star property
7.8 out of 10, Good, (527)
"Ok"
The price is NT$2,327
NT$2,722 total
includes taxes & fees
Mar 2 - Mar 3
La Quinta Inn & Suites by Wyndham Pasadena North
Bluestar Inn
Individually furnished, desk, iron/ironing board, free WiFi

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (195)
"Amazing i love it i will be back soon"
The price is NT$2,386
NT$2,791 total
includes taxes & fees
Feb 2 - Feb 3
Bluestar Inn
Best Western Plus Heritage Inn
Reception

Best Western Plus Heritage Inn

3.0 star property
8.0 out of 10, Very Good, (583)
"Excellent value "
The price is NT$2,559
NT$2,994 total
includes taxes & fees
Feb 2 - Feb 3
Best Western Plus Heritage Inn
Woodspring Suites South Houston Hobby
Suite, 1 King Bed, Non Smoking | Individually furnished, desk, laptop workspace, bed sheets

Woodspring Suites South Houston Hobby

2.5 star property
7.8 out of 10, Good, (133)
"All good"
The price is NT$1,928
NT$2,256 total
includes taxes & fees
Feb 2 - Feb 3
Woodspring Suites South Houston Hobby
Sonesta Essential Houston Hobby Airport
Lobby

Sonesta Essential Houston Hobby Airport

2.5 star property
6.6 out of 10, (1001)
"Hotel is obviously in the midst of an upgrade. You can still find some items of the former named hotel around. TVs, bedding, carpet all newer upgrades. Breakfast needs some work, but change tales time and plenty of breakfast spots close by. Great Mexican restaurant next door."
The price is NT$1,639
NT$2,109 total
includes taxes & fees
Feb 18 - Feb 19
Sonesta Essential Houston Hobby Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in South Main
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center, an IHG Hotel and Wyndham Houston near NRG Park/Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 66 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.