Find Resorts & Hotels with Spas in Hannibal, MO

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Pick from 10 Hannibal Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Sleep Inn & Suites
2.5 star property
9.6 out of 10, Exceptional, (1008)
"Easy stop on the way hunting "
The price is NT$3,094
NT$3,553 total
includes taxes & fees
Dec 8 - Dec 9
Sleep Inn & Suites
Comfort Inn & Suites - Hannibal
2.5 star property
7.6 out of 10, Good, (527)
"Room was clean. Plenty of space."
The price is NT$2,762
NT$3,270 total
includes taxes & fees
Nov 24 - Nov 25
Comfort Inn & Suites - Hannibal
Motel 6 Hannibal, MO
2.0 star property
7.4 out of 10, Good, (1002)
"The room wasn't anything fancy but was clean and the bed was comfortable."
The price is NT$1,819
NT$2,090 total
includes taxes & fees
Dec 1 - Dec 2
Motel 6 Hannibal, MO
Howard Johnson BY Wyndham Hannibal
2.0 star property
7.0 out of 10, Good, (98)
"Hv"
The price is NT$1,995
NT$2,293 total
includes taxes & fees
Nov 24 - Nov 25
Howard Johnson BY Wyndham Hannibal
Baymont by Wyndham Hannibal
2.5 star property
6.0 out of 10, (597)
"It was a good hotel. "
The price is NT$1,881
NT$2,163 total
includes taxes & fees
Dec 21 - Dec 22
Baymont by Wyndham Hannibal
Days Inn by Wyndham Hannibal
2.0 star property
7.2 out of 10, Good, (131)
"Nice staff, store and gas next door."
The price is NT$2,340
NT$2,687 total
includes taxes & fees
Nov 24 - Nov 25
Days Inn by Wyndham Hannibal
Super 8 by Wyndham Hannibal
2.0 star property
7.2 out of 10, Good, (1006)
"Great!"
The price is NT$2,281
NT$2,620 total
includes taxes & fees
Dec 16 - Dec 17
Super 8 by Wyndham Hannibal
Best Western On The River
2.5 star property
8.6 out of 10, Excellent, (1007)
"The only inconvenience was we stayed in the adjacent building and had to walk through the parking lot for breakfast or to use pool/hot tub. "
The price is NT$3,477
NT$3,993 total
includes taxes & fees
Nov 25 - Nov 26
Best Western On The River
Garth Woodside Mansion B&B
3.5 star property
9.6 out of 10, Exceptional, (16)
"Quiet and isolated in a wooded area."
Garth Woodside Mansion B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking to vacation at a spa hotel in Hannibal?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers recommend the gourmet restaurants in Hannibal. Enjoy the shopping and riverfront during your vacation. Spa hotels are a great way to break out of your routine and add a layer of luxury to your vacation.
What is the best spa hotel in Hannibal?
Comfort Inn & Suites - Hannibal is a top spa hotel featuring a 24-hour fitness center and an indoor pool. Kick back and relax in the spa tub.
How many spa hotels are there in Hannibal?
Among Expedia’s 50 accommodation options in Hannibal, there is 1 spa hotel.
What's there to see and do in Hannibal?
Take in the sights and attractions that Hannibal offers with a visit to Mark Twain Boyhood Home and Museum, Mark Twain Cave and Cameron Cave, and Mark Twain Cave. If you have a little extra time during your trip, you might want to check out Mississippi River and Big River Train Town.
What is a Hannibal spa hotel?
Spa hotels in Hannibal provide lodging and have an on-site spa offering services such as couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.