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Find hotels in Cherokee Seneca, Louisville

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Our top choices for Cherokee Seneca hotels

Tru by Hilton Shepherdsville Louisville South

Tru by Hilton Shepherdsville Louisville South
2.5 star property
19.1 km from Cherokee Seneca
9.2 out of 10, Wonderful, (839)
"Very modern....loved it"
United States
Lisa
The price is NT$2,557
NT$2,846 total
includes taxes & fees
Jan 4 - 2026/1/5
Tru by Hilton Shepherdsville Louisville South

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
8.8 out of 10, Excellent, (1002)
"Enjoyed our stay "
United States
Jedediah
The price is NT$3,137
NT$3,691 total
includes taxes & fees
Dec 27 - Dec 28
Hyatt Regency Louisville

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 6.5 km from Cherokee Seneca
9.0 out of 10, Wonderful, (3881)
"Beautiful room and great hospitality. "
United States
Chase
The price is NT$4,181
NT$4,919 total
includes taxes & fees
Dec 21 - Dec 22
Galt House Hotel Trademark Collection by Wyndham

Holiday Inn Express Hotel & Suites Louisville East by IHG

Holiday Inn Express Hotel & Suites Louisville East by IHG
2.5 star property
Jeffersontown, 13.1 km from Cherokee Seneca
9.2 out of 10, Wonderful, (756)
"Very good breakfast and friendly staff. The room very spacious and very clean"
United States
Khanh
The price is NT$2,425
NT$2,853 total
includes taxes & fees
Dec 19 - Dec 20
Holiday Inn Express Hotel & Suites Louisville East by IHG

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville, 7 km from Cherokee Seneca
9.2 out of 10, Wonderful, (1000)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is NT$4,378
NT$5,309 total
includes taxes & fees
Jan 1 - 2026/1/2
21c Museum Hotel Louisville

Wingate by Wyndham Louisville Fair and Expo

Wingate by Wyndham Louisville Fair and Expo
2.5 star property
3.7 km from Cherokee Seneca
8.4 out of 10, Very Good, (1180)
"Place was nice and staff very friendly"
United States
Thelma
The price is NT$2,092
NT$2,461 total
includes taxes & fees
Jan 12 - 2026/1/13
Wingate by Wyndham Louisville Fair and Expo

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
3.0 star property
Downtown Louisville, 6.9 km from Cherokee Seneca
9.2 out of 10, Wonderful, (1007)
"The room was wonderful and the staff exceptional."
United States
Daniel
The price is NT$3,215
NT$3,783 total
includes taxes & fees
Jan 9 - 2026/1/10
Homewood Suites by Hilton Louisville Downtown, KY

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 6.2 km from Cherokee Seneca
9.2 out of 10, Wonderful, (1735)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is NT$5,244
NT$6,171 total
includes taxes & fees
Jan 2 - 2026/1/3
Omni Louisville Hotel

Hampton Inn Simpsonville

Hampton Inn Simpsonville
2.5 star property
29.6 km from Cherokee Seneca
9.4 out of 10, Exceptional, (902)
"Would stay again"
United States
Chris
The price is NT$2,803
NT$3,120 total
includes taxes & fees
Dec 26 - Dec 27
Hampton Inn Simpsonville

La Quinta Inn & Suites by Wyndham Louisville NE/Old Henry Rd

La Quinta Inn & Suites by Wyndham Louisville NE/Old Henry Rd
3.0 star property
17.2 km from Cherokee Seneca
8.4 out of 10, Very Good, (921)
"Room was very clean. Staff were nice. "
United States
Cazza
The price is NT$2,419
NT$2,846 total
includes taxes & fees
Jan 6 - 2026/1/7
La Quinta Inn & Suites by Wyndham Louisville NE/Old Henry Rd

Fairfield Inn & Suites by Marriott Louisville Shepherdsville

Fairfield Inn & Suites by Marriott Louisville Shepherdsville
2.5 star property
19.2 km from Cherokee Seneca
9.4 out of 10, Exceptional, (405)
"Honestly the cleanest place we have stayed at in a long time . All employees were wonderful , the breakfast was great and clean ."
United States
Kenneth
The price is NT$2,917
NT$3,247 total
includes taxes & fees
Dec 22 - Dec 23
Fairfield Inn & Suites by Marriott Louisville Shepherdsville

Caesars Southern Indiana - A Caesars Rewards Destination

Caesars Southern Indiana - A Caesars Rewards Destination
3.5 star property
20.2 km from Cherokee Seneca
8.2 out of 10, Very Good, (1003)
"The room was very clean, the staff was very friendly and helpful."
United States
Judy
The price is NT$2,243
NT$3,119 total
includes taxes & fees
Dec 18 - Dec 19
Caesars Southern Indiana - A Caesars Rewards Destination

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1115)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is NT$3,575
NT$4,206 total
includes taxes & fees
Dec 28 - Dec 29
Embassy Suites Louisville Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG
2.5 star property
Downtown Louisville, 7.1 km from Cherokee Seneca
8.8 out of 10, Excellent, (1652)
"very clean throughout, helpful staff,very nice breakfast"
United States
Wayne
The price is NT$2,572
NT$3,026 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Express & Suites Louisville Downtown by IHG

Courtyard by Marriott Louisville Airport

Courtyard by Marriott Louisville Airport
3.0 star property
7.1 km from Cherokee Seneca
9.0 out of 10, Wonderful, (333)
"Staff were very nice and airport shuttle was prompt "
United States
Alexandria
The price is NT$3,074
NT$3,617 total
includes taxes & fees
Dec 19 - Dec 20
Courtyard by Marriott Louisville Airport

Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
3.0 star property
Downtown Louisville, 7.1 km from Cherokee Seneca
9.2 out of 10, Wonderful, (509)
"Accommodations were perfect. Staff excellent. Food was very good."
United States
Bennett
The price is NT$3,043
NT$3,580 total
includes taxes & fees
Jan 11 - 2026/1/12
Towneplace Suites By Marriott Louisville Downtown

Derby City Gaming & Hotel - A Churchill Downs Property

Derby City Gaming & Hotel - A Churchill Downs Property
4.0 star property
6 km from Cherokee Seneca
9.4 out of 10, Exceptional, (1694)
"Great place to stay"
United States
april
Derby City Gaming & Hotel - A Churchill Downs Property

Hyatt House Louisville East

Hyatt House Louisville East
2.0 star property
9.2 km from Cherokee Seneca
9.6 out of 10, Exceptional, (1004)
"Friendly people, pleasant all around stay. Excellent breakfast and night staff. Would definitely stay here again."
United States
Krista
The price is NT$2,917
NT$3,432 total
includes taxes & fees
Dec 23 - Dec 24
Hyatt House Louisville East

Drury Inn & Suites Louisville North

Drury Inn & Suites Louisville North
3.0 star property
12.5 km from Cherokee Seneca
9.6 out of 10, Exceptional, (1000)
"Always enjoy the Drury Inn!"
United States
Dorothy
The price is NT$3,136
NT$3,690 total
includes taxes & fees
Dec 22 - Dec 23
Drury Inn & Suites Louisville North

Home2 Suites By Hilton Shepherdsville Louisville South

Home2 Suites By Hilton Shepherdsville Louisville South
3.0 star property
27.9 km from Cherokee Seneca
9.4 out of 10, Exceptional, (238)
"Nice place to spend time with family outside the rooms."
United States
Christopher
The price is NT$3,074
NT$3,421 total
includes taxes & fees
Jan 1 - 2026/1/2
Home2 Suites By Hilton Shepherdsville Louisville South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most.

Downtown Louisville

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

Fairgrounds

While visiting Fairgrounds, you might make a stop by sights like Freedom Hall and Kentucky Kingdom.

Jeffersontown

Jeffersontown is known for its abundant dining options, and you can plan a trip to Jeffersontown Commons Shopping Center and Bluegrass Indoor Karting while you're in town.

St. Matthews

Major shopping destination with the fifth-largest mall in Kentucky, Mall St. Matthews, and smaller centers along Shelbyville Road. Don't miss the historic St. Matthew's Episcopal Church and Holy Trinity.

Old Louisville

Boasting Victorian architecture and the highest concentration of stained glass windows in residential homes, Old Louisville offers a walkable neighborhood with pedestrian-only streets, diverse dining options, and attractions like Central Park and the Conrad-Caldwell House.

Top Cherokee Seneca Hotel Reviews

Frequently asked questions

What is Cherokee Seneca like?
You'll be sure to have fun visiting Louisville's Cherokee Seneca neighborhood.
If I need to cancel my hotel reservation in Cherokee Seneca, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to review top deals in Cherokee Seneca.
Where can I learn more about changing or cancelling my trip to Cherokee Seneca?
To find more details about changing or cancelling your trip to Cherokee Seneca, head over to our customer service page.
What is there to do around this Louisville neighborhood?
Peterson-Dumesnil House, Historic Frankfort Avenue, and Colonel Sanders' Grave are just a few of the places to visit in and around Cherokee Seneca. Muhammad Ali Gravesite and Mid City Mall Shopping Center are also worth a visit when you're out sightseeing in Louisville.

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