Find All Southeast Missouri Hotels
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Find All Southeast Missouri Hotels
We have found 554 Southeast Missouri Hotels
- The Riverview
- Drury Plaza Hotel Cape Girardeau Conference Center
- Baymont Inn and Suites by Wyndham Farmington, MO
- Motel 6 Poplar Bluff, MO
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- The Farmstead Hotel
- Pear Tree Inn Sikeston
- Pear Tree Inn Cape Girardeau West
- Fairfield Inn & Suites by Marriott Poplar Bluff
- Candlewood Suites Cape Girardeau by IHG
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Best Western Plus Sikeston
- Drury Inn & Suites Sikeston, MO
- Drury Inn & Suites Cape Girardeau
- New Orleans Inn Portageville
- Courtyard by Marriott Cape Girardeau Downtown
- Days Inn and Suites by Wyndham Sikeston
- Comfort Inn Festus - St Louis South
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Quality Inn
- Drury Inn & Suites Jackson MO
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Super 8 by Wyndham Perryville
- Drury Inn & Suites Hayti Caruthersville
- Town House Inn Cape Giradreau
- Hampton Inn Poplar Bluff
- Super 8 by Wyndham Bonne Terre
- Hampton Inn Sikeston
- Comfort Inn Poplar Bluff North
- Quality Inn Farmington
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Holiday Inn Express & Suites Perryville by IHG
- Super 8 by Wyndham Farmington
- Hampton Inn Cape Girardeau I 55 East
- Holiday Inn Poplar Bluff by IHG
- Drury Inn & Suites Poplar Bluff
- Comfort Suites Jackson-Cape Girardeau
- Microtel Inn & Suites by Wyndham Sainte Genevieve
- Tru By Hilton Cape Girardeau
- Echo Bluff State Park
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Super 8 by Wyndham Poplar Bluff Missouri
- Honeysuckle Inn - Mountain View
- Holiday Inn Express & Suites Sikeston Southwest by IHG
- Hampton Inn Farmington
- Quality Inn Festus
- Crown Pointe Lodge, BW Signature Collection
- Shepherd Mountain Inn
- Econo Lodge
- Super 8 by Wyndham Potosi
- Super 8 By Wyndham Marston
- Century Casino & Hotel Caruthersville
- Quality Inn Hayti North
- Country Yard Inn and Suite
- Town House Inn
- Madison Inn Lodge
- Bullwinkles Rustic Lodge
- Super 8 by Wyndham Charleston/Sikeston East MO
- Comfort Inn & Suites Sikeston I-55
- Quality Inn Perryville I-55
- Holiday Inn Express & Suites Farmington by IHG
- Days Inn by Wyndham Perryville
- Super 8 by Wyndham Kennett
- Quality Inn Charleston - Sikeston
- Dexter Inn
- Econo Lodge Dexter
- Super 8 by Wyndham Sikeston/Miner Area
- Travelodge by Wyndham Dexter
- Current River Inn
- Travel Inn
- OYO Hickory House Inn
- Fort Davidson Hotel
- TownePlace Suites by Marriott Sikeston
- EC Reed's Mercantile and Hotel
- OYO Malden Airport Inn
- Rockwood Inn
- Black River Motel and Restaurant
- Super 8 by Wyndham Pevely
- Motel 6 Bonne Terre, MO
- Arcadia Academy
- Wilderness Lodge
- Fairfield by Marriott Inn & Suites Sikeston
- Eagle Inn Charleston
- Rosener's Inn and banquet center
Let Expedia take you to the best Hotels in Southeast Missouri. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.